*
Mesothelioma: is a form of
cancer that is almost always caused by exposure to asbestos and it is most frequently arises from the cells lining the
sacs of the chest (the pleura) or the abdomen (the peritoneum).
*Most people who develop mesothelioma have worked on jobs where they
inhaled asbestos particles, or they have been exposed to asbestos dust
and fiber in other ways.
Pleural mesothelioma is
the most common form, often presenting with symptoms in the chest area.
Peritoneal mesothelioma is much less common. This can effect the organs
in the abdomen, and its symptoms are related to this area of the body,
that is, abdominal swelling, nausea, vomiting, and bowel obstruction.
The rarest form of mesothelioma is pericardial mesothelioma, which
involves the sac surrounding the heart.It has also been suggested that washing the
clothes of a family member who worked with asbestos can put a person at
risk for developing mesothelioma. Unlike
lung cancer,
there is no association between mesothelioma and smoking, but smoking
greatly increases risk of other asbestos-induced cancer. Compensation
via asbestos funds or lawsuits is an important issue in mesothelioma
(see asbestos and the law).
*There are two major
cell types
of mesothelioma, epithelial and sarcomatoid. Sometimes both of these
cell types can be present. The sarcomatoid type is rarer and occurs in
only about 15% of cases; it portends a poorer prognosis. In very rare
cases, mesothelioma can originate from benign, non-malignant cells. This
so-called benign mesothelioma can be cured surgically.
*The symptoms of mesothelioma include shortness of breath due to pleural
effusion (fluid between the lung and the chest wall) or chest wall pain,
and general symptoms such as weight loss. The diagnosis may be
suspected with chest X-ray and CT scan, and is confirmed with a
biopsy
(tissue sample) and microscopic examination. A thoracoscopy (inserting a
tube with a camera into the chest) can be used to take biopsies. It
allows the introduction of substances such as talc to obliterate the
pleural space (called pleurodesis), which prevents more fluid from
accumulating and pressing on the lung. Despite treatment with
chemotherapy,
radiation therapy
or sometimes surgery, the disease carries a poor prognosis. Research
about screening tests for the early detection of mesothelioma is
ongoing.